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Journal Papers
23. A. Nandagiri, A. Gaikwad, D. Potter, R. Nosrati, J. Soria, M. O’Bryan, S. Jadhav, R. Prabhakar (2021) Flagellar energetics from high-resolution imaging of beating patterns in tethered mouse sperm. eLife 10, e62524.
22. S. A. Vasilescu, S. Khorsandi, L. Ding, S. Razavi Bazaz, R. Nosrati, D. Gook, M. Ebrahimi Warkiani (2021) A microfluidic approach to sperm recovery from mixed cell suspension. Scientific Reports 11, 7917.
21. S. Xiao, J. Riordon, M. Simchi, A. Lagunov, T. Hannam, K. Jarvi, R. Nosrati, D. Sinton (2021) FertDish: Microfluidic sperm selection-in-a-dish for intracytoplasmic sperm injection. Lab on a Chip 21, 775-783.
20. J. Gai, R. Nosrati†, A. Neild† (2020) High DNA integrity sperm selection using surface acoustic waves. Lab on a Chip 20, 4262-4272. † Co-corresponding authors.
Interview with 7News.
Featured in over 20 public news media worldwide including Herald Sun, EurekAlert, Phys.org, medianet, Scimex, BioNews, News-Medical, ScienMag, Firstpost, ConSalud (Spanish), and Capital.gr (Greek)
19. A. Lesani, S. Kazemnejad, M. Moghimi Zand, M. Azadi, H. Jafari, M.R.K. Mofrad, R. Nosrati (2020) Quantification of human sperm concentration using machine learning-based spectrophotometry. Computers in Biology and Medicine 127, 104061.
18. J. Zhou, R. Habibi, F. Akbaridoust, A. Neild, R. Nosrati (2020) Paper-based acoustofluidics for separating particles and cells. Analytical Chemistry 92, 8569-8578.
17. S. Rismani Yazdi, R. Nosrati, C. Stevens, D. Vogel, C. Escobedo (2018) Migration of magnetotactic bacteria in porous media. Biomicrofluidics 12, 011101.
Selected as a Featured Article
16. S. Rismani Yazdi, R. Nosrati, C. Stevens, D. Vogel, P. Davies, C. Escobedo (2018) Magnetotaxis enables magnetotactic bacteria to navigate in flow. Small 14, 1702982.
Featured on the front cover of this issue
Featured in Phys.org, EurekAlert, Science Daily, Nanowerk, and Queen’s gazette
15. H. Dies*, R. Nosrati*, J. Raveendran, C. Escobedo, A. Docoslis (2018) SERS-from-scratch: an electric field-guided nanoparticle assembly method for cleanroom-free and low-cost preparation of surface-enhanced Raman scattering substrates. Colloids and Surfaces A: Physicochemical and Engineering Aspects 553, 695-702.
* Equal contributions.
14. R. Nosrati, P. J. Graham, B. Zhang, J. Riordon, A. Lagunov, T. G. Hannam, C. Escobedo, K. A. Jarvi, D. Sinton (2017) Microfluidics for sperm analysis and selection. Nature Reviews Urology 14, 707-730.
Featured on the home page of Nature Reviews Urology, December 2017
13. R. Nosrati, M. M. Gong, M. C. San Gabriel, A. Zini, D. Sinton (2016) Paper-based sperm DNA integrity analysis. Analytical Methods 8, 6260-6264.
Featured on the front cover of this issue
12. R. Nosrati, P. J. Graham, Q. Liu, D. Sinton (2016) Predominance of sperm motion in corners. Scientific Reports 6, 26669.
11. L. Eamer*, M. Vollmer*, R. Nosrati*, M. C. San Gabriel, K. Zeidan, A. Zini, D. Sinton (2016) Turning the corner in fertility: high DNA integrity of boundary-following sperm. Lab on a Chip 16, 2418-2422.
* Equal contributions.
Featured on the inside front cover of this issue
10. R. Nosrati, M. M. Gong, M. C. San Gabriel, C. E. Pedraza, A. Zini, D. Sinton (2016) Paper-based quantification of male fertility potential. Clinical Chemistry 62, 458-465.
Highlighted in a Clinical Chemistry Editorial 62, 421 (2016)
Featured in Daily Mail UK, The Sun, and Pembe Nar (Turkish)
9. R. Nosrati, A. Driouchi, C. M. Yip, D. Sinton (2015) Two-dimensional slither swimming of sperm within a micrometre of a surface. Nature Communications 6, 8703.
Highlighted in Nature Reviews Urology 13, 2 (2016)
Featured in over 20 public news media worldwide including The Scientist, Tech Times, LA Times, Daily Mail UK, MSN News, The Star, Popular Science, The Sun, slate (French), Lentra (Russian),
bild der wissenschaft (German), sina (Chinese), Nature Communications Press Release, Nature Asia, and U of T Engineering News
8. M. M. Gong, R. Nosrati, M. C. San Gabriel, A. Zini, D. Sinton (2015) Direct DNA analysis with paper-based ion concentration polarization. Journal of the American Chemical Society 137, 13913-13919.
Highlighted in ACS PressPac, Chemical & Engineering News, and Science Daily
7. L. Eamer*, R. Nosrati*, M. Vollmer, A. Zini, D. Sinton (2015) Microfluidic assessment of swimming media for motility-based sperm selection. Biomicrofluidics 9, 044113.
* Equal contributions.
6. R. Nosrati, M. Vollmer, L. Eamer, M. C. San Gabriel, K. Zeidan, A. Zini, D. Sinton (2014) Rapid selection of sperm with high DNA integrity. Lab on a Chip 14, 1142-1150.
Reached #6 on the Top-20 downloaded papers from this journal over 30 days
5. R. Nosrati, M. Hadigol, M. Raisee, A. Nourbakhsh (2012) Numerical modeling of electroosmotic nanoflows with overlapped electric double layer. Journal of Computational and Theoretical Nanoscience 9, 2228-2239.
4. M. Hadigol, R. Nosrati, M. Raisee (2011) Numerical analysis of mixed electroosmotic/pressure driven flow of power-law fluids in microchannels and micropumps. Colloids and Surfaces A: Physicochemical and Engineering Aspects 374, 142-153.
3. M. Hadigol, R. Nosrati, A. Nourbakhsh, M. Raisee (2011) Numerical study of electroosmotic micromixing of non-Newtonian fluids. Journal of Non-Newtonian Fluid Mechanics 166, 965-971.
2. R. Nosrati, M. Hadigol, A. Jafari, M. Raisee, A. Nourbakhsh (2011) Numerical investigation of electroosmotic mixing in microchannels with heterogeneous zeta potential. Advanced Science, Engineering and Medicine 3, 253-261.
1. R. Nosrati, M. Hadigol, M. Raisee (2010) The effect of Y-component electroosmotic body force in mix electroosmotic/pressure driven microflows. Colloids and Surfaces A: Physicochemical and Engineering Aspects 372, 190-195.
Journal Papers
42. M. Simchi, J. Riordon, Y. Wang, C. McCallum, J. Bem You, K. Jarvi, R. Nosrati, D. Sinton (2023) High-throughput sperm DNA analysis at the single-cell and population levels. Analyst https://doi.org/10.1039/D3AN00564J
41. S. Xiao, J. Riordon, A. Lagunov, M. Ghaffarzadeh, T. Hannam, R. Nosrati, D. Sinton (2023) Human sperm cooperate to transit highly viscous regions on the competitive pathway to fertilization. Communications Biology 6, 495. https://doi.org/10.1038/s42003-023-04875-2
40. S. Zeaei, M. Zabetian Targhi, I. Halvaei, R. Nosrati (2023) High-DNA integrity sperm selection using rheotaxis and boundary following behavior in a microfluidic chip. Lab on a Chip 23, 2241-2248. https://doi.org/10.1039/D2LC01190E
39. S.A. Vasilescu, L. Ding, F. Yazdan Parast, R. Nosrati, M. Ebrahimi Warkiani (2023) Sperm quality metrics were improved by a biomimetic microfluidic selection platform compared to swim-up methods. Microsystems & Nanoengineering 9, 37. https://doi.org/10.1038/s41378-023-00501-7
Featured in over 10 public news media worldwide including Science Daily, EurekAlert, Science Magazine, Tech Times, Medical Press, and News-Medical
38. V. Omrani, M. Zabetian Targhi, F. Rahbarizadeh, R. Nosrati (2023) High-throughput isolation of cancer cells in spiral microchannel by changing the direction, magnitude and location of the maximum velocity. Scientific Reports 13, 3213. https://doi.org/10.1038/s41598-023-30275-x
37. J. Castro, M. Abdul Halim, L. Ambattu, A. Rezk, R. Prabhakar, R. Nosrati, L. Yeo (2023) Acoustofluidic semen analysis for veterinary male bovine infertility assessment. Flow 3, E6. https://doi.org/10.1017/flo.2022.30
36. A. Heydari, M. Zabetian Targhi, I. Halvaei, R. Nosrati (2023) A novel microfluidic device with parallel channels for sperm separation using spermatozoa intrinsic behaviors. Scientific Reports 13(1), 1185. https://doi.org/10.1038/s41598-023-28315-7
35. J. Gai, C. Devendran, A. Neild, R. Nosrati (2022) Surface acoustic wave-driven pumpless flow for sperm rheotaxis analysis. Lab on a Chip https://doi.org/10.1039/D2LC00803C
34. L. Spencer, J. Fernando, F. Akbaridoust, K. Ackermann, R. Nosrati (2022) Ensembled Deep Learning for the Classification of Human Sperm Head Morphology. Advanced Intelligent systems 2200111. https://doi.org/10.1002/aisy.202200111
33. R. Nosrati (2022) Lab on a Chip devices for fertility: from proof-of-concept to clinical impact. Lab on a Chip 22, 1680-1689. Invited Perspective. https://doi.org/10.1039/D1LC01144H
Featured in the themed collection: "Lab on a Chip HOT Articles 2022"
32. F. Yazdan Parast, M.K. O’Bryan, R. Nosrati (2022) Sperm syringe: 3D sorting platform for assisted reproduction. Advanced Materials Technology 2101291. https://doi.org/10.1002/admt.202101291
31. J. Gai, E. Dervisevic, C. Devendran, V. J. Cadarso, M. K. O’Bryan, R. Nosrati†, A. Neild† (2022) High-frequency ultrasound boosts sperm motility. Advanced Science 2104362. https://doi.org/10.1002/advs.202104362 † Co-corresponding authors
30. S. Powar, F. Yazdan Parast, A. Nandagiri, A.S. Gaikwad, D. Potter, M.K. O’Bryan, R. Prabhakar, J. Soria, R. Nosrati (2022) Unravelling the kinematics of sperm motion by reconstructing the flagellar wave motion in 3D. Small Methods 6, 2101089.
29. R. Nosrati, D. Sinton (2022) How to select ICSI-viable sperm from the most challenging samples. Nature Reviews Urology 19, 135-136.
28. M.R. Raveshi, M. Abdul Halim, S.N. Agnihotri, M.K. O’Bryan, A. Neild, R. Nosrati (2021) Curvature in the reproductive tract alters sperm–surface interactions. Nature Communications 12, 3446.
Featured in Editors’ Highlights as the 50 best papers in “From molecules and cells to organisms” recently published in Nature Communications.
Featured in news media worldwide including Herald Sun, BioNews, scimex, medianet, and Mirage News
27. I. Ramazani Sarbandi, A. Lesani, M. Moghimi Zand, R. Nosrati (2021) Rheotaxis-based sperm separation using a biomimicry microfluidic device. Scientific Reports 11, 18327.
26. A. Gaikwad, A. Nandagiri, D. Potter, R. Nosrati, A. O'Connor, S. Jadhav, J. Soria, R. Prabharkar, M. O'Bryan (2021) CRISPs function to boost sperm power output and motility. Frontiers in Cell and Developmental Biology 9, 693258.
25. J. B. You, C. McCallum, Y. Wang, J. Riordon, R. Nosrati, D. Sinton (2021) Machine learning for sperm selection. Nature Reviews Urology 18, 387-403.
24. M. Simchi, J. Riordon, J. B. You, Y. Wang, S. Xiao, A. Lagunov, T. Hannam, K. Jarvi, R. Nosrati†, and D. Sinton† (2021) Clinical selection of high-quality sperm with thousands of parallel selection channels. Lab on a Chip 21, 2464-2475. † Co-corresponding authors.
Conference Proceedings and Presentations
27. M.R. Raveshi, M. Abdul Halim, A. Neild, R. Nosrati. The role of interface curvature on sperm behaviour. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2019), Basel, Switzerland, October 27-31, 2019.
26. A. Lesani, S. Kazemnejad, H. Mousavi, M. Moghimi Zand, R. Nosrati. Sperm motility improvement on nano-diamond coated glass substrates. 20th Royan International Congress on Reproductive Biomedicine, Tehran, Iran, August 28-30, 2019.
25. M. Abdul Halim, M.R. Raveshi, A. Neild, R. Nosrati. Droplet-based sperm motility analysis. 2019 Australia and New Zealand Nano and Microfluidics meeting (ANZNMF 2019), Wollongong, Australia, July 1-3, 2019.
24. J. Gai, R. Nosrati, A. Neild. Acoustic based microfluidic method for spermatozoa separation. 2019 Australia and New Zealand Nano and Microfluidics meeting (ANZNMF 2019), Wollongong, Australia, July 1-3, 2019.
23. J. Roth, R. Nosrati, C. Escobedo. Application of deterministic lateral displacement for cell separation. 3rd Annual Queen’s/RMC ChemEng Research Day, Queen’s University, Kingston, Canada, September 8, 2017.
22. S. R. Yazdi, D. Vogel, C. Stevens, R. Nosrati, P. Davies, C. Escobedo. Magnetotaxis enables the magnetotactic bacteria to navigate in strong flows. 2nd Annual Queen’s/RMC ChemEng Research Day, Queen’s University, Kingston, Canada, September 9, 2017.
21. B. Zhang, R. Nosrati, L. Maghen, A. Lagunov, T.G. Hannam, D. Sinton. Paper-based quantification of human sperm DNA fragmentation. 62nd Annual Meeting of Canadian Fertility and Andrology Society (CFAS), Toronto, Canada, September 22-24, 2016.
20. K. Zeidan, M. C. San Gabriel, R. Nosrati, L.Eamer, M. Vollmer, D. Sinton, A. Zini. Rapid selection of motile sperm with high DNA integrity using microfluidics. American Society of Andrology 40th Annual Conference, Salt Lake City, UT, April 18-21, 2015.
19. M. C. San Gabriel, K. Zeidan, K. Alrabeeah, R. Nosrati, L. Eamer, M. Vollmer, D. Sinton, A. Zini. Comparative study of microfluidic device (MFD) and density gradient centrifugation (DGC) in selecting sperm with high DNA integrity. American Society of Andrology 40th Annual Conference, Salt Lake City, UT, April 18-21, 2015.
18. R. Nosrati, P.J. Graham, D. Sinton. Corner accumulation behavior of spermatozoa in microchannels. 4th Micro and Nano Flows Conference (MNF2014), London, UK, September 7-10, 2014.
17. K. Zeidan, M. San Gabriel, R. Nosrati, L. Eamer, M. Vollmer, D. Sinton, A. Zini. Rapid selection of motile sperm with high DNA integrity using microfluidics. 60th Annual Meeting of the Canadian Fertility and Andrology Society (CFAS), Quebec City, Canada, September 11-14, 2014.
16. M. San Gabriel, K. Zeidan, K. Alrabeeah, R. Nosrati, L. Eamer, M. Vollmer, D. Sinton, A. Zini. Comparative study of microfluidic device (MFD) and density gradient centrifugation (DGC) in selecting sperm with high DNA integrity. 60th Annual Meeting of the Canadian Fertility and Andrology Society (CFAS), Quebec City, Canada, September 11-14, 2014
.
15. R. Nosrati, A. Driouchi, C.M. Yip, D. Sinton. Analyzing near wall sperm motion using TIRF microscopy. CSME International Congress 2014, Toronto, Canada, June 1-4, 2014.
14. R. Nosrati, A. Driouchi, C.M. Yip, D. Sinton. Near-surface sperm hydrodynamics using TIRF microscopy. 9th Ontario-on-a-Chip Symposium (OOAC9/MATCH), Toronto, Canada, May 29-30, 2014.
13. R. Nosrati, A. Driouchi, K.J. Downie, A.Vissa, C.M. Yip, D. Sinton. Near-surface hydrodynamics of spermatozoa by total internal reflection fluorescence microscopy. 1st international conference on Micro & Nanofluidics (Flow14), Enschede, The Netherlands, May 18-21, 2014.
Awarded Best Poster award
12. K. Zeidan, R. Nosrati, L. Eamer, M. Vollmer, M. San Gabriel, D. Sinton, A. Zini. High-throughput microfluidic device for motile sperm selection. American Society of Reproductive Medicine (ASRM) 69th Annual Meeting in Fertility and Sterility 100 (3), S220, Boston, MA, October 12-17, 2013.
11. L. Eamer, R. Nosrati, M. Vollmer, D. Sinton. Microfluidics separation of sperm based on total progressive motility. 4th Annual MIE Research Symposium 2013, Toronto, Canada, June 10, 2013.
10. R. Nosrati, L. Eamer, M. Vollmer, D. Sinton. High-throughput viable sperm separation on-a-chip with milliliter-scale sample capacity. 4th Annual MIE Research Symposium 2013, Toronto, Canada, June 10, 2013.
9. R. Nosrati, K. Zeidan, M. Vollmer, L.Eamer, M. San Gabriel, A. Zini, D. Sinton. Viable sperm separation on-a-chip with millilitre-scale sample capacity. Advances in Microfluidics & Nanofluidics (AMN), Notre Dame, IN, May 24-26, 2013.
8. R. Potyrailo, D. Sinton, Y. Lee, R. Nosrati. Toward rapid detection of biological particles using multivariable resonant label-free biosensors. 245th ACS National Meeting & Exposition, New Orleans, LA, April 7-11, 2013.
7. R. Nosrati, M. Vollmer, L.Eamer, K. Zeidan, M. San Gabriel, A. Zini, D. Sinton. Microfluidic separation of motile sperm with millilitre-scale sample capacity. 65th Annual Meeting of the American Physical Society's Division of Fluid Dynamics (DFD), San Diego, CA, November 18-20, 2012.
6. R. Nosrati, M. Vollmer, L.Eamer, D. Sinton. Millilitre-scale sperm sorting for assisted reproductive technology (ART). 2nd Annual MIE Research Symposium 2012, Toronto, Canada, June 4, 2012.
Awarded Best Poster Presentation Award in Biomedical Engineering
5. L. Eamer, M. Vollmer, R. Nosrati, D. Sinton. Microfluidic separation of sperm based on total progressive motility in high viscosity media. 2nd Annual MIE Research Symposium 2012, Toronto, Canada, June 4, 2012.
4. M. Vollmer, R. Nosrati, L.Eamer, D. Sinton. High-throughput sperm motility assay and automated selection for clinical in vitro fertilization. 7th Ontario-on-a-Chip Symposium (OOAC7/MATCH), Toronto, Canada, May 17-18, 2012.
3. R. Nosrati, M. Raisee, A. Nourbakhsh. Modeling of electroosmotic nanoflows with overlapped double layer. Proceedings of the ASME 9th International Conference on Nanochannels, Microchannels, and Minichannels (ICNMM2011), Edmonton, Canada, ICNMM2011-58087, 265-276, June 19-22, 2011.
2. R. Nosrati, M. Hadigol, A. Nourbakhsh, M. Raisee. Numerical study of micromixing in mixed electroosmotic/pressure driven microflows. ASME 2011 International Mechanical Engineering Congress and Exposition (IMECE2011), Denver, CO, November 11-17, 2011.
1. M. Hadigol, R. Nosrati, M. Raisee. Mixed electroosmotic/pressure driven flow of power-law fluids in slit microchannels. 6th IEEE International Conference on MEMS, Nano and Smart Systems (ICMENS2010), Changsha, China, December 14-15, 2010.
Patents and Invention Disclosures
9. 1. F. Yazdan Parast, M.K. O’Bryan, R. Nosrati. Apparatus for separating micro-swimmers. Australian Provisional Patent Application No. 2021904063, Filed 14 December 2021.
8. J. Gai, C. Devendran, R. Nosrati, A. Neild. Method and apparatus to boost sperm motility using high frequency ultrasound. Australian Provisional Patent Application No. 2021904104, Filed 17 December 2021.
7. J. Zhou, A. Neild, R. Habibi, R. Nosrati. Apparatus and methods for manipulating particles and cells in paper-based platforms using ultrasound. Australian Provisional Patent Application Ref. No. AU2019904519, filed November 29, 2019.
6. R. Nosrati, L. Eamer, M. Vollmer, D. Sinton, A. Zini. Apparatus and method for sperm separation. U.S. Patent No. 14/547,606, Canada Patent No. 2834007, Brazilian Patent Application No. BR102014028937, May 30, 2017.
5. R. Nosrati, M. M. Gong, D. Sinton. Devices and methods for quantification of male fertility. U.S. Provisional Patent Application No. 62/258,178, filed November 20, 2015.
4. M. M. Gong, R. Nosrati, D. Sinton. Devices and methods for nucleic acid detection. U.S. Provisional Patent Application No. 62/258,242, filed November 20, 2015.
3. R. Nosrati, M. M. Gong, D. Sinton. Quantitative semen analysis in paper-based microfluidic assays. University of Toronto Confidential Invention Disclosure #10003012, filed October 14, 2015.
2. M. M. Gong, R. Nosrati, D. Sinton. Nucleic acid analysis in paper-based assays with ion concentration polarization. University of Toronto Confidential Invention Disclosure #10003013, filed October 14, 2015.
1. R. Nosrati, L. Eamer, M. Vollmer, D. Sinton. High-throughput sperm separation device for the use in Artificial Reproductive Technologies (ARTs). University of Toronto Confidential Invention Disclosure #10002635, filed July 18, 2013.
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